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Arguello Amy Arguello
Assistant Professor
Ph.D. UT Southwestern Medical Center at Dallas, Dallas, TX, Basic Sciences 2009
Bachelors St. Mary's University, San Antonio, TX, Biology 2004
Primary Program: Behavioral Neuroscience
213A Giltner
(517) 355-7462

Research Statement

The main goal of the Arguello Lab is to examine how neural substrates and subcircuits promote drug relapse. Specifically, we are interested in the interaction between the lateral orbitofrontal cortex and basolateral amygdala and how these regions contribute to cue-induced relapse. The lab utilizes multidisciplinary approaches to answer these questions, including western blotting, immunohistochemistry, in vivo viral and optogenetic manipulations, in combination with a rodent model of drug relapse.


Current Projects

Current Projects are funded through an NIH K99/R00 Pathway to Independence Award (NIDA 4R00DA037271-03). The goal of the R00 portion of this grant is to examine the role of novel, subregional orbitofrontal-basolateral amygala circuits in cue-induced reinstatement of cocaine-seeking behavior.

Related Research Websites
Arguello Lab Projects People Contact How do complex brain circuits interact to potentiate drug relapse?
Arguello Lab Projects People Contact How do complex brain circuits interact to potentiate drug relapse?

Research Publications    
2016Wells AM, Xie X, Higginbotham JA, Arguello AA, Healey KL, Blanton M, Fuchs RA (2016). Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats. Neuropsychopharmacology: Feb;41(3):675-85.
2016Arguello AA, Richardson BD, Hall JL, Wang R, Hodges MA, Mitchell MP, Stuber GD, Rossi DJ, Fuchs RA (2016). Role of a Lateral Orbital Frontal Cortex-Basolateral Amygdala Circuit in Cue-Induced Cocaine-Seeking Behavior. Neuropsychopharmacology: Aug 18. doi: 10.1038/npp.2016.157.
2014Lasseter HC, Xie X, Arguello AA, Wells AM, Hodges MA, Fuchs RA (2014). Contribution of a mesocorticolimbic subcircuit to drug context-induced reinstatement of cocaine-seeking behavior in rats. Neuropsychopharmacology: Feb;39(3):660-9.
2014Arguello AA, Hodges MA, Wells AM, Lara H 3rd, Xie X, Fuchs RA (2014). Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats. Psychopharmacology (Berl): Jan;231(1):55-65.
2013Xie X, Arguello AA, Wells AM, Reittinger AM, Fuchs RA (2013). Role of a hippocampal SRC-family kinase-mediated glutamatergic mechanism in drug context-induced cocaine seeking. Neuropsychopharmacology: Dec;38(13):2657-65.
2013Arguello AA, Ye X, Bozdagi O, Pollonini G, Tronel S, Bambah-Mukku D, Huntley GW, Platano D, Alberini CM (2013). CCAAT enhancer binding protein d plays an essential role in memory consolidation and reconsolidation. J Neurosci: Feb 20;33(8):3646-58.
2013Wells AM, Arguello AA, Xie X, Blanton MA, Lasseter HC, Reittinger AM, Fuchs RA (2013). Extracellular signal-regulated kinase in the basolateral amygdala, but not the nucleus accumbens core, is critical for context-response-cocaine memory reconsolidation in rats. Neuropsychopharmacology: Apr;38(5):753-62.
2012Xie X, Arguello AA, Reittinger AM, Wells AM, Fuchs RA (2012). Role of nicotinic acetylcholine receptors in the effects of cocaine-paired contextual stimuli on impulsive decision making in rats. Psychopharmacology (Berl): Oct;223(3):271-9.
2009Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ (2009). Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience: Mar 31;159(3):1003-10.
2008Arguello AA, Harburg GC, Schonborn JR, Mandyam CD, Yamaguchi M, Eisch AJ (2008). Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience: Nov 11;157(1):70-9.