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Breedlove Marc Breedlove
Barnett Rosenberg Professor of Neuroscience
Ph.D. University of California, Los Angeles, Physiological Psychology 1982
Masters University of California, Los Angeles, Psychology 1978
Bachelors Yale University, New Haven, CT, cum laude, Psychology 1976
Primary Program: Behavioral Neuroscience
108 Giltner
(517) 355-1749

Research Statement
The Breedlove lab studies how steroid hormones influence the developing and adult nervous system, including the generation of sex differences in the brain and spinal cord, and the implications of these sex differences for behavior in animals and humans.

Related Research Websites
The Breedlove Jordan Lab We are interested in hormonal modulation of the developing and adult nervous system that leads to changes in behavior. Steroid hormones such as testosterone can alter the survival and differentiation of glia, neurons and target tissues such as muscle. Using a range of rodent species, we try to understand which cells directly respond to the hormone, which genes are regulated in those cells, and how the structure and function of the cell changes as a consequence of that gene regulation.

Research Publications    
2011Minireview: Organizational hypothesis: instances of the fingerpost. Endocrinology. 2010 Sep;151(9):4116-22.
2011Zuloaga DG, Jordan CL, Breedlove SM. (2011) The organizational role of testicular hormones and the androgen receptor in anxiety-related behaviors and sensorimotor gating in rats. Endocrinology. 2011 Apr;152(4):1572-81. Epub 2011 Feb 15.
2010Ottem EN, Poort JE, Wang H, Jordan CL, Breedlove SM. (2010) Differential expression and regulation of brain-derived neurotrophic factor (BDNF) mRNA isoforms in androgen-sensitive motoneurons of the rat lumbar spinal cord. Mol Cell Endocrinol. 328(1-2):40-6.
2008Johnson, R.T., S.M.Breedlove & C.L.Jordan (2008) Sex differences and laterality in astrocyte number and complexity in the adult rat medial amygdala. Journal of Comparative Neurology, 511: 599-609.
2008Bucci, D.J., Hopkins, M.E., Nunez, A.A., Breedlove, S.M., Sisk, C.L, and Nigg, J.T. (2008) Effects of sex hormones on associative learning in the spontaneously hypertensive rat. Physiology and Behavior 93:651-57.
2008Zuloaga, D.G., D.A.Puts, C.L.Jordan & S.M.Breedlove (2008) The role of androgen receptors in the masculinization of brain & behavior: What we’ve learned from the testicular feminization mutation (Tfm). Hormones and Behavior, 53: 613-626.
2008Culbert, K.M., S.M.Breedlove, S.A.Burt & K.L.Klump (2008). Prenatal testosterone exposure and risk for eating disorders: a comparison of opposite-sex and same-sex twins. Archives of General Psychiatry, 65: 329-336.
2008Puts, D.A., M.A.McDaniel, C.L.Jordan & S.M.Breedlove (2008) Spatial ability and prenatal androgens: meta-analysis of CAH and digit ratio studies. Archives Sexual Behavior, 37: 100-111.
2008Morris, J.A., C.L.Jordan, Z.A.King, K.V.Northcutt & S.M.Breedlove (2008) Sexual dimorphism and steroid responsiveness of the posterodorsal medial amygdala in adult mice. Brain Research, 1190: 115-121.
2008Zuloaga, D.G. & S.M.Breedlove (2008?) Sexual differentiation of the central nervous system. Encyclopedia of Neuroscience in press.