Arguello Photo

Amy Arguello vita

Assistant Professor

PhD, Division of Basic Sciences, Neuroscience Program, UT Southwestern Medical Center at Dallas, Dallas, TX, 2009
BS, Biology, St. Mary’s University, San Antonio, TX, 2004

Research Statement

The main goal of the Arguello Lab is to examine how neural substrates and subcircuits promote drug relapse. Specifically, we are interested in the interaction between the lateral orbitofrontal cortex and basolateral amygdala and how these regions contribute to cue-induced relapse. The lab utilizes multidisciplinary approaches to answer these questions, including western blotting, immunohistochemistry, in vivo viral and optogenetic manipulations, in combination with a rodent model of drug relapse.

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Selected Publications

  • Wells AM, Xie X, Higginbotham JA, Arguello AA, Healey KL, Blanton M, Fuchs RA
    Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats.
    2016, Neuropsychopharmacology, 41:675-85
  • Arguello AA, Richardson BD, Hall JL, Wang R, Hodges MA, Mitchell MP, Stuber GD, Rossi DJ, Fuchs RA
    Role of a Lateral Orbital Frontal Cortex-Basolateral Amygdala Circuit in Cue-Induced Cocaine-Seeking Behavior
    2016, Neuropsychopharmacology
  • Lasseter HC, Xie X, Arguello AA, Wells AM, Hodeges MA, Fuchs RA
    Contribution of a mesocorticolimbic subcircuit to drug context-induced reinstatement of cocaine-seeking behavior in rats.
    2014, Neuropsychopharmacology, 39:660-9
  • Arguello AA, Hodges MA, Wells AM, Lara H 3rd, Xie X, Fuchs RA
    Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats
    2014, Psychopharmacology (Berl): Jan, 231:55-65
  • Xie X, Arguello AA, Wells AM, Reittinger AM, Fuchs RA
    Role of a hippocampal SRC-family kinase-mediated glutamatergic mechanism in drug context-induced cocaine seeking
    2013, Neuropsychopharmacology: Dec, 38:2657-65
  • Arguello AA, Ye X, Bozdagi O, Pollonini G, Tronel S, Bambah-Mukku D, Huntley GW, Platano D, Alberini CM
    CCAAT enhancer binding protein d plays an essential role in memory consolidation and reconsolidation
    2013, J Neurosci: Feb 20, 33:3646-58
  • Wells AM, Arguello AA, Xie X, Blanton MA, Lasseter HC, Reittinger AM, Fuchs RA
    Extracellular signal-regulated kinase in the basolateral amygdala, but not the nucleus accumbens core, is critical for context-response-cocaine memory reconsolidation in rats
    2013, Neuropsychopharmacology: Apr, 38:753-62
  • Xie X, Arguello AA, Reittinger AM, Wells AM, Fuchs RA
    Role of nicotinic acetylcholine receptors in the effects of cocaine-paired contextual stimuli on impulsive decision making in rats
    2012, Psychopharmacology (Berl): Oct, 223:271-9
  • Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ
    Effect of chronic morphine on the dentate gyrus neurogenic microenvironment
    2012, Neuroscience: Mar 31, 159:1003-10
  • Arguello AA, Harburg GC, Schonborn JR, Mandyam CD, Yamaguchi M, Eisch AJ
    Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons.
    2012, Neuroscience: Nov 11, 157:70-9
  • Fischer SJ, Arguello AA, Charlton JJ, Fuller DC, Zachariou V, Eisch AJ
    Morphine blood levels, dependence, and regulation of hippocampal subgranular zone proliferation rely on administration paradigm
    2012, Neuroscience: Feb 19, 151:1217-24
  • Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD, Eisch AJ
    Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
    2012, J Neurosci: Nov 14, 27:12623-9
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