The main goal of the Arguello Lab is to examine how neural substrates and subcircuits promote drug relapse. Specifically, we are interested in
the interaction between the lateral orbitofrontal cortex and basolateral amygdala and how these regions contribute to cue-induced
relapse. The lab utilizes multidisciplinary approaches to answer these questions, including western blotting, immunohistochemistry, in vivo
viral and optogenetic manipulations, in combination with a rodent model of drug relapse.