Thakkar Katherine Square

Katharine Thakkar CV

Assistant Professor

PhD, Psychology, Vanderbilt University, 2012
BA, Psychology, Boston University, 2004
BA, Mathematics, Boston University, 2004

Research Statement

My research program aims to understand the biological basis of psychotic disorders, namely schizophrenia. More specifically, I use translational methods, largely grounded in animal neurophysiology, to examine the basic building blocks of impaired cognition, disrupted social abilities, and the core disturbances in the sense of self purported to characterize psychosis. Understanding these most basic impairments that give rise to the profound cognitive, social, and psychotic symptoms of schizophrenia can help us pinpoint disturbances in specific functional circuitry. A deeper understanding of these symptoms and their mechanisms will eventually lead to more targeted behavioral and pharmacological treatment options. To explore the neurobiology of psychotic disorders, I use a variety of approaches including eye tracking, functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), behavioral experiments, and first-person accounts of experience.

Related Programs

Selected Publications

  • Thakkar, K.N., Rösler, L., Wijnen, J.P., Boer, V.O., Klomp, D.W.J., Cahn, W., Kahn, R.S., Neggers, S.F.W.
    7T proton magnetic resonance spectroscopy of GABA, glutamate, and glutamine reveals altered concentrations in schizophrenia patients and healthy siblings
    2017, Biological Psychiatry, 81:515-535
  • Thakkar, K.N., Diwadkar, V., Rolfs, M.
    Oculomotor prediction: a window into the psychotic mind
    2017, Trends in Cognitive Sciences
  • Thakkar, K.N., van den Heiligenberg, F. Kahn, R.S., Neggers, S.F.W.
    Fronto-striatal contributions to reactive control of gaze
    2014, Journal of Neuroscience, 34:(26): 8918-8929
  • Thakkar, K.N., Peterman, J.S., Park, S.
    Altered brain activation during action imitation and observation in schizophrenia: a translational approach for studying social dysfunction
    2014, American Journal of Psychiatry, 171:(5): 539-548
  • more publications