Wade Juli Vertical

Juli Wade CV

Professor, Chairperson

BA, Psychology, Cornell University, 1987
PhD, Psychology, University of Texas, 1992

Research Statement

We seek to understand how structural and biochemical changes within the central nervous system regulate behavior. One effective method for investigating this topic is the exploitation of naturally occurring differences in behaviors. We study courtship and copulatory displays because they are stereotyped, sexually differentiated, and in many species displayed seasonally. Therefore, we can evaluate mechanisms regulating behaviors within a sex in and out of the breeding season, as well as between the two sexes. We focus on factors involved both in organizing critical  regions of the brain, spinal cord and muscles during development, as well as those that confer varying levels of plasticity in adulthood.  Members of my lab are working with two model systems, songbirds and  anole lizards.  These species have the potential to not only increase understanding of the evolution of the processes regulating behavioral differences, which have commonly been studied in mammals, but also to address the ubiquity of the mechanisms employed in diverse situations.  Our techniques currently range from molecular to behavioral, with emphases also on measurements of steroid hormones, their receptors and metabolizing enzymes, and the morphology of anatomical structures related to reproduction.  Integrating work across multiple levels of analysis and appreciating the differences and similarities across diverse vertebrate systems facilitates our understanding of factors controlling nervous system structure and function.

Related Programs

Selected Publications

  • Wade, J.
    Genetic regulation of sex differences in songbirds and lizards
    2016, Phil. Trans. R. Soc. B., 371:20150112
  • Beach, L.Q., Tang, Y.P., Kerver, H. and Wade, J.
    Inhibition of TrkB limits development of the zebra finch song system
    2016, Brain Res., 1642:467-477
  • Kerver, H.N. and Wade, J.
    Sexually dimorphic expression of CREB binding protein in the green anole brain
    2016, Gen. Comp. Endocrinol., 225:55-60
  • Tang, Y.P. and Wade, J.
    Sex and age differences in brain derived neurotrophic factor and vimentin in the zebra finch song system: Relationships to newly generated cells
    2016, J. Comp. Neurol., 524:1081-1096
  • Beach, L.Q. and Wade, J.
    Masculinisation of the zebra finch song system: Roles of oestradiol and the Z-chromosome gene tubulin specific chaperone protein A
    2015, J. Neuroendocrinol., 24:324-334
  • Kerver, H.N and Wade, J.
    Hormonal regulation of steroid receptor coactivator-1 mRNA in the male and female green anole brain
    2015, J. Neuroendocrinol., 27:223-233
  • Kerver, H.N. and Wade, J.
    Relationships among sex, season, and testosterone in the expression of androgen receptor mRNA and protein in the green anole forebrain
    2014, Brain Behav. Evol., 84:303-314
  • Lampen, J., Jones, K., McAuley, J.D., Chang, S.-E., and Wade, J.
    Arrhythmic song exposure increases zenk expression in auditory cortical areas and nucleus taeniae of the adult zebra finch
    2014, PLoS ONE, 9:e108841
  • Tang, Y.P. and Wade, J.
    Tracheosyringeal nerve transection in juvenile male zebra finches decreases BDNF in HVC and RA and the projection between them
    2014, Neurosci. Lett., 583:26-31
  • more publications